HA dermal fillers typically fall into one of two categories: biphasic or monophasic. Biphasic HA products consist of particles of stabilized HA gel suspended in a non-stabilized HA fluid. In contrast, monophasic HA products, such as Revanesse®, are made entirely of stabilized, non-particle, HA gel. The benefit of this approach is two fold.
First, the body's breakdown of biphasic HA differs from that of monophasic HA. Biphasic HA experiences a rapid initial degradation of the non-stabilized HA carrier fluid and a slower degradation of the stabilized HA gel; to combat this effect the physician will over-correct to compensate for the initial rapid degradation. This can lead to less than satisfactory results.
In contrast, monophasic HA degrades in a simple, consistent manner, allowing the physician to correct to the desired look thereby taking the guess work out of the final outcome. Second, in monophasic fillers, the entire volume of the syringe is filled with fine, soft gel particles packed together. This uniform composition leads to the desirable qualities of smoothness, uniformity, and accurate filling.
