The safety of the Revanesse® family of fillers is our utmost concern. The HA used in the Revanesse® family of products is obtained through biosynthesis, making it safe and non pathogenic for humans. With less than 0.025 IU/mg of endotoxins and less than 2 ppm of protein, it exceeds the highest standard of purity for HA. The Revanesse® line of dermal fillers is completely free of all animal products, thus reducing the risk of an immunogenic reaction. The HA utilized in the Revanesse® product line is naturally integrated into the tissue keeping the skin looking healthy and natural.